Cellosaurus logo
expasy logo

Cellosaurus H1-HeLa+CHDR3 (CVCL_C8ZH)

[Text version]
Cell line name H1-HeLa+CHDR3
Accession CVCL_C8ZH
Resource Identification Initiative To cite this cell line use: H1-HeLa+CHDR3 (RRID:CVCL_C8ZH)
Comments Population: African American.
Virology: Supports replication of rhinovirus C15 (RV-C15) and Enterovirus D68 (EV-D68) (PubMed=31527793).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 26308; CDHR3 (Note=With p.Cys529Tyr).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: CRISPR phenotypic screen.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3334 (H1HeLa)
Children:
CVCL_C8ZI (H1-HeLa+CDHR3 SETD3KO)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=31527793; DOI=10.1038/s41564-019-0551-1; PMCID=PMC6879830
Diep J., Ooi Y.S., Wilkinson A.W., Peters C.E., Foy E.M., Johnson J.R., Zengel J., Ding S.-Y., Weng K.-F., Laufman O., Jang G., Xu J.-W., Young T., Verschueren E., Kobluk K.J., Elias J.E., Sarnow P., Greenberg H.B., Huttenhain R., Nagamine C.M., Andino-Pavlovsky R., Krogan N.J., Gozani O.P., Carette J.E.
Enterovirus pathogenesis requires the host methyltransferase SETD3.
Nat. Microbiol. 4:2523-2537(2019)

Cross-references
CRISP screens repositories BioGRID_ORCS_Cell_line; 1180
Encyclopedic resources Wikidata; Q123031385
Entry history
Entry creation05-Oct-2023
Last entry update10-Sep-2024
Version number3