ID   YUL-0019
AC   CVCL_C8TI
DR   Wikidata; Q123033990
RX   PubMed=29686424;
RX   PubMed=35820397;
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Asn771delinsPheHis (N771delinsFH); Zygosity=Unspecified (PubMed=29686424).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 19-12-24; Version: 3
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RX   PubMed=29686424; DOI=10.1038/s41591-018-0007-9; PMCID=PMC5964608;
RA   Robichaux J.P., Elamin Y.Y., Tan Z., Carter B.W., Zhang S.-X.,
RA   Liu S.-W., Li S., Chen T., Poteete A., Estrada-Bernal A., Le A.T.,
RA   Truini A., Nilsson M.B., Sun H.-Y., Roarty E., Goldberg S.B.,
RA   Brahmer J.R., Altan M., Lu C., Papadimitrakopoulou V., Politi K.,
RA   Doebele R.C., Wong K.-K., Heymach J.V.;
RT   "Mechanisms and clinical activity of an EGFR and HER2 exon
RT   20-selective kinase inhibitor in non-small cell lung cancer.";
RL   Nat. Med. 24:638-646(2018).
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RX   PubMed=35820397; DOI=10.1016/j.ccell.2022.06.006; PMCID=PMC9667883;
RA   Elamin Y.Y., Robichaux J.P., Carter B.W., Altan M., Tran H.,
RA   Gibbons D.L., Heeke S., Fossella F.V., Lam V.K., Le X.-N., Negrao M.V.,
RA   Nilsson M.B., Patel A., Vijayan R.S.K., Cross J.B., Zhang J.-J.,
RA   Byers L.A., Lu C., Cascone T., Feng L., Luthra R., San Lucas F.A.,
RA   Mantha G., Routbort M.J., Blumenschein G.R. Jr., Tsao A.S., Heymach J.V.;
RT   "Poziotinib for EGFR exon 20-mutant NSCLC: clinical efficacy,
RT   resistance mechanisms, and impact of insertion location on drug
RT   sensitivity.";
RL   Cancer Cell 40:754-767.e6(2022).
//