ID   YU-1077
AC   CVCL_C8TD
SY   YU1077
DR   ArrayExpress; E-MTAB-11342
DR   Wikidata; Q123033971
RX   PubMed=31882684;
RX   PubMed=35933914;
CC   Population: Korean.
CC   Doubling time: 20 +- 0.8 hours (PubMed=35933914).
CC   Sequence variation: Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E6A20 v3 fusion (PubMed=31882684; PubMed=35933914).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=35933914).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=35933914).
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Gly1202Arg (c.3604G>A); ClinVar=VCV000376134; Zygosity=Heterozygous (PubMed=31882684; PubMed=35933914).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (PubMed=35933914).
CC   Omics: Genome sequenced.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 19-12-24; Version: 3
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RX   PubMed=31882684; DOI=10.1038/s41598-019-56356-4; PMCID=PMC6934824;
RA   Kim S.-Y., Lee J.Y., Kim D.H., Joo H.-S., Yun M.R., Jung D., Yun J.,
RA   Heo S.G., Ahn B.-C., Park C.W., Pyo K.H., Chun Y.J., Hong M.H.,
RA   Kim H.R., Cho B.C.;
RT   "Patient-derived cells to guide targeted therapy for advanced lung
RT   adenocarcinoma.";
RL   Sci. Rep. 9:19909-19909(2019).
//
RX   PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010;
RA   Bokhari A.A.A., Lai W.-Y., Le A.T., Gabre J.L., Chuang T.-P.,
RA   Fransson S., Bergman B., Djos A., Chen N., Martinsson T.,
RA   Van den Eynden J., Doebele R.C., Palmer R.H., Hallberg B., Umapathy G.;
RT   "Novel human-derived EML4-ALK fusion cell lines identify
RT   ribonucleotide reductase RRM2 as a target of activated ALK in
RT   NSCLC.";
RL   Lung Cancer 171:103-114(2022).
//