Cellosaurus cell line CUTO-29 (CVCL

Cellosaurus CUTO-29 (CVCL_C8TC)

Cross-references
Cell line name	CUTO-29
Synonyms	CUTO29; Colorado University Thoracic Oncology 29
Accession	CVCL_C8TC
Resource Identification Initiative	To cite this cell line use: CUTO-29 (RRID:CVCL_C8TC)
Comments	Doubling time: 37 +- 1.3 hours (PubMed=35933914). Omics: Genome sequenced. Omics: SNP array analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations	Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E6A19 v3 fusion (PubMed=35933914). Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=35933914). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=35933914). Gene deletion; HGNC; HGNC:7325; MSH2; Zygosity=Homozygous (PubMed=35933914). Mutation; HGNC; HGNC:427; ALK; Simple; p.Cys1156Tyr (c.3467G>A); ClinVar=VCV000376340; Zygosity=Heterozygous (PubMed=35933914). Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg680Ter (c.2038C>T); ClinVar=VCV000036572; Zygosity=Heterozygous (PubMed=35933914). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys277Tyr (c.830G>A); ClinVar=VCV000185722; Zygosity=Homozygous (PubMed=35933914).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	54Y
Category	Cancer cell line
Publications	PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010 Bokhari A.A.A., Lai W.-Y., Le A.T., Gabre J.L., Chuang T.-P., Fransson S., Bergman B., Djos A., Chen N., Martinsson T., Van den Eynden J., Doebele R.C., Palmer R.H., Hallberg B., Umapathy G. Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC. Lung Cancer 171:103-114(2022)
Encyclopedic resources	Wikidata; Q123030994
Gene expression databases	ArrayExpress; E-MTAB-11342
Entry history
Entry creation	05-Oct-2023
Last entry update	19-Dec-2024
Version number	3