Cellosaurus cell line CUTO-33 (CVCL

Cellosaurus CUTO-33 (CVCL_C8T0)

Cross-references
Cell line name	CUTO-33
Synonyms	CUTO33; Colorado University Thoracic Oncology 33
Accession	CVCL_C8T0
Resource Identification Initiative	To cite this cell line use: CUTO-33 (RRID:CVCL_C8T0)
Comments	Omics: Transcriptomics; RNAseq. Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations	Gene fusion; HGNC; HGNC:1697; CD74 + HGNC; HGNC:10261; ROS1; Name(s)=CD74-ROS1 (PubMed=30538120; PubMed=37727007). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Trp146Ter (c.437G>A); ClinVar=VCV000634785; Zygosity=Unspecified (PubMed=37727007).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	65Y
Category	Cancer cell line
Publications	PubMed=30538120; DOI=10.1158/0008-5472.CAN-18-1492; PMCID=PMC6359944 Neel D.S., Allegakoen D.V., Olivas V., Mayekar M.K., Hemmati G., Chatterjee N., Blakely C.M., McCoach C.E., Rotow J.K., Le A.T., Karachaliou N., Rosell R., Riess J.W., Nichols R., Doebele R.C., Bivona T.G. Differential subcellular localization regulates oncogenic signaling by ROS1 kinase fusion proteins. Cancer Res. 79:546-556(2019) PubMed=37727007; DOI=10.1111/1759-7714.15116; PMCID=PMC10665781 Peters T.L., Chen N., Tyler L.C., Le A.T., Dimou A., Doebele R.C. Intrinsic resistance to ROS1 inhibition in a patient with CD74-ROS1 mediated by AXL overexpression. Thorac. Cancer 14:3259-3265(2023)
Encyclopedic resources	Wikidata; Q123030996
Gene expression databases	GEO; GSM7675373 GEO; GSM7675374 GEO; GSM7675375 GEO; GSM7675376 GEO; GSM7675377 GEO; GSM7675378
Entry history
Entry creation	05-Oct-2023
Last entry update	10-Apr-2025
Version number	5