Cellosaurus BCLC-5-C8.1/miR122 (CVCL_C8JN)
| Cell line name | BCLC-5-C8.1/miR122 |
|---|---|
| Accession | CVCL_C8JN |
| Resource Identification Initiative | To cite this cell line use: BCLC-5-C8.1/miR122 (RRID:CVCL_C8JN) |
| Comments | Characteristics: Transfected with a construct containing a neomycin resistance selectable marker (SGR-JFH1-neo) and cured of HCV RNA by interferon-alpha treatment and with a construct containing miR122 and GFP (PubMed=28751105). Virology: Exhibits enhanced hepatitis C virus (HCV) RNA replication compared to parent cell line (PubMed=28751105). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:31501; MIR122. Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Liver; UBERON=UBERON_0002107. Cell type: Epithelial cell; CL=CL_0000066. |
| Disease | Hepatitis C infection (NCIt: C3098) Adult hepatocellular carcinoma (NCIt: C7956) Cirrhosis (NCIt: C2951) Adult hepatocellular carcinoma (ORDO: Orphanet_210159) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_C8JL (BCLC-5-C8.1) |
| Sex of cell | Female |
| Age at sampling | 48Y |
| Category | Cancer cell line |
| Publications | PubMed=28751105; DOI=10.1016/j.virusres.2017.07.018 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q123030776 |
| Entry history | |
| Entry creation | 05-Oct-2023 |
| Last entry update | 19-Dec-2024 |
| Version number | 4 |