ID   Caco-2H
AC   CVCL_C8JI
DR   Wikidata; Q123030847
RX   PubMed=8253353;
CC   Population: Caucasian.
CC   Characteristics: Control cell line for Caco-2MT (Cellosaurus=CVCL_C8JJ) and Caco-2T (Cellosaurus=CVCL_C8JK).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
//
RX   PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t;
RA   Chastre E., Empereur S., Di Gioia Y., El Mahdani N., Mareel M.M.,
RA   Vleminckx K.L., Van Roy F.M., Bex V., Emami S., Spandidos D.A.,
RA   Gespach C.;
RT   "Neoplastic progression of human and rat intestinal cell lines after
RT   transfer of the ras and polyoma middle T oncogenes.";
RL   Gastroenterology 105:1776-1789(1993).
//