ID   HL-60(DM)
AC   CVCL_C8HP
SY   HL-60 (DM)
DR   Wikidata; Q123031676
RX   PubMed=3475162;
CC   Population: Caucasian.
CC   Karyotypic information: Contains a variable number (from 1 to 37) of double minute chromosomes (PubMed=3475162).
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
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RX   PubMed=3475162; DOI=10.1016/0165-4608(87)90362-1;
RA   Misawa S.-i., Staal S.P., Testa J.R.;
RT   "Amplification of the c-myc oncogene is associated with an abnormally
RT   banded region on chromosome 8 or double minute chromosomes in two
RT   HL-60 human leukemia sublines.";
RL   Cancer Genet. Cytogenet. 28:127-135(1987).
//