ID   RPE1-SS119
AC   CVCL_C8DN
SY   RPE1SS119
DR   DepMap; ACH-002465
DR   Wikidata; Q123033370
RX   PubMed=33505028;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Characteristics: This cell line has a stable aneuploid karyotype, the parent cell line was transiently treated with the TTK inhibitor reversine to induce random chromosome gains and losses (PubMed=33505028).
CC   Karyotypic information: Contains an extra Chr 8 (PubMed=33505028).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4388 ! hTERT-RPE1
SX   Female
AG   1Y
CA   Telomerase immortalized cell line
DT   Created: 29-06-23; Last updated: 19-12-24; Version: 5
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RX   PubMed=33505028; DOI=10.1038/s41586-020-03114-6; PMCID=PMC8262644;
RA   Cohen-Sharir Y., McFarland J.M., Abdusamad M., Marquis C.,
RA   Bernhard S.V., Kazachkova M., Tang H., Ippolito M.R., Laue K.,
RA   Zerbib J., Malaby H.L.H., Jones A., Stautmeister L.-M., Bockaj I.,
RA   Wardenaar R., Lyons N., Nagaraja A.K., Bass A.J., Spierings D.C.J.,
RA   Foijer F., Beroukhim R., Santaguida S., Golub T.R., Stumpff J.,
RA   Storchova Z., Ben-David U.;
RT   "Aneuploidy renders cancer cells vulnerable to mitotic checkpoint
RT   inhibition.";
RL   Nature 590:486-491(2021).
//