Cell line name |
J82/MMC |
Accession |
CVCL_C8D4 |
Resource Identification Initiative |
To cite this cell line use: J82/MMC (RRID:CVCL_C8D4) |
Comments |
Population: Caucasian; Swedish. Selected for resistance to: ChEBI; CHEBI_27504; Mitomycin C (MMC; MitC). Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Ser770Pro (c.2308T>C); ClinVar=VCV000140988; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro124Leu (c.371C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs*1 (c.635_1212del578); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; c.2107-2A>G; ClinVar=VCV000013077; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys320Asn (c.960G>C); Zygosity=Heterozygous (from parent cell line).
|
Disease |
Bladder carcinoma (NCIt: C4912) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0359 (J82) |
Sex of cell |
Male |
Age at sampling |
58Y |
Category |
Cancer cell line |
Publications | PubMed=8077054; DOI=10.1002/ijc.2910580512 Xu B.H., Gupta V., Singh S.V. Characterization of a human bladder cancer cell line selected for resistance to mitomycin C. Int. J. Cancer 58:686-692(1994) PubMed=7729958; DOI=10.1002/ijc.2910610326 Singh S.V., Xu B.H., Jani J.P., Emerson E.O., Backes M.G., Rihn C., Scalamogna D., Stemmler N., Specht S., Blanock K., Katoh A., Gupta V. Mechanism of cross-resistance to cisplatin in a mitomycin C-resistant human bladder cancer cell line. Int. J. Cancer 61:431-436(1995) |
Cross-references |
Encyclopedic resources |
Wikidata; Q123032760
|
Entry history |
Entry creation | 29-Jun-2023 |
Last entry update | 19-Dec-2024 |
Version number | 3 |
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