ID   PaCa 5061
AC   CVCL_C886
SY   PaCa-5061; PaCa5061
DR   cancercelllines; CVCL_C886
DR   Cosmic; 1352405
DR   IARC_TP53; 28456
DR   Wikidata; Q54937416
RX   DOI=10.4172/2324-9293.1000104;
RX   PubMed=20553613;
RX   PubMed=21632553;
RX   PubMed=22490524;
CC   Doubling time: 30-48 hours (PubMed=20553613).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20553613).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=20553613).
CC   Omics: CNV analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 16
//
RX   DOI=10.4172/2324-9293.1000104;
RA   Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R.,
RA   Saeger H.-D.;
RT   "Distribution of characteristic mutations in native ductal
RT   adenocarcinoma of the pancreas and pancreatic cancer cell lines.";
RL   Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).
//
RX   PubMed=20553613; DOI=10.1186/1471-2407-10-295; PMCID=PMC2927995;
RA   Kalinina T., Gungor C., Thieltges S., Moller-Krull M., Murga Penas E.-M.,
RA   Wicklein D., Streichert T., Schumacher U., Kalinin V., Simon R.,
RA   Otto B., Dierlamm J., Schwarzenbach H., Effenberger K.E., Bockhorn M.,
RA   Izbicki J.R., Yekebas E.F.;
RT   "Establishment and characterization of a new human pancreatic
RT   adenocarcinoma cell line with high metastatic potential to the lung.";
RL   BMC Cancer 10:295.1-295.13(2010).
//
RX   PubMed=21632553; DOI=10.1158/0008-5472.CAN-11-0036;
RA   Gungor C., Zander H., Effenberger K.E., Vashist Y.K., Kalinina T.,
RA   Izbicki J.R., Yekebas E.F., Bockhorn M.;
RT   "Notch signaling activated by replication stress-induced expression of
RT   midkine drives epithelial-mesenchymal transition and chemoresistance
RT   in pancreatic cancer.";
RL   Cancer Res. 71:5009-5019(2011).
//
RX   PubMed=22490524; DOI=10.1136/gutjnl-2011-300629;
RA   Gebauer F., Wicklein D., Stubke K., Nehmann N., Schmidt A.,
RA   Salamon J., Peldschus K., Nentwich M.F., Adam G., Tolstonog G.V.,
RA   Bockhorn M., Izbicki J.R., Wagener C., Schumacher U.;
RT   "Selectin binding is essential for peritoneal carcinomatosis in a
RT   xenograft model of human pancreatic adenocarcinoma in pfp--/rag2--
RT   mice.";
RL   Gut 62:741-750(2013).
//