ID   44As3Luc
AC   CVCL_C7UQ
DR   JCRB; JCRB1893
DR   JCRB; NIHS1328
DR   Wikidata; Q123030281
RX   PubMed=19010905;
RX   PubMed=26934957;
CC   Population: Japanese.
CC   Characteristics: Highly metastatic. Strong capability of inducing the formation of ascites.
CC   Characteristics: Grand-parent cell line was injected subcutaneously into BALB/c nude mice. Cells from metastatic ascitic tumor cells were harvested and re-injected into mice. This process was carried out 12 times.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Discontinued: JCRB; NIHS1328; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): JCRB=JCRB1893
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8
ST   D16S539: 13
ST   D5S818: 10
ST   D7S820: 11
ST   TH01: 8,9
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C5250; Gastric signet ring cell adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_XG62 ! 44As3
SX   Female
AG   28Y
CA   Cancer cell line
DT   Created: 29-06-23; Last updated: 19-12-24; Version: 5
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RX   PubMed=19010905; DOI=10.1158/0008-5472.CAN-08-2822;
RA   Nakajima T.E., Yanagihara K., Takigahira M., Yasunaga M., Kato K.,
RA   Hamaguchi T., Yamada Y., Shimada Y., Mihara K., Ochiya T.,
RA   Matsumura Y.;
RT   "Antitumor effect of SN-38-releasing polymeric micelles, NK012, on
RT   spontaneous peritoneal metastases from orthotopic gastric cancer in
RT   mice compared with irinotecan.";
RL   Cancer Res. 68:9318-9322(2008).
//
RX   PubMed=26934957; DOI=10.1038/srep22371; PMCID=PMC4776110;
RA   Kurashige J., Hasegawa T., Niida A., Sugimachi K., Deng N., Mima K.,
RA   Uchi R., Sawada G., Takahashi Y., Eguchi H., Inomata M., Kitano S.,
RA   Fukagawa T., Sasako M., Sasaki H., Sasaki S., Mori M., Yanagihara K.,
RA   Baba H., Miyano S., Tan P., Mimori K.;
RT   "Integrated molecular profiling of human gastric cancer identifies
RT   DDR2 as a potential regulator of peritoneal dissemination.";
RL   Sci. Rep. 6:22371-22371(2016).
//