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Cellosaurus HME50-8 (CVCL_C7SX)

[Text version]
Cell line name HME50-8
Accession CVCL_C7SX
Resource Identification Initiative To cite this cell line use: HME50-8 (RRID:CVCL_C7SX)
Comments Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met133Thr (c.398T>C); ClinVar=VCV000012357; Zygosity=Heterozygous (from parent cell line).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C7T1 (HME50)
Children:
CVCL_C7T3 (HME50-8R)CVCL_C7T4 (HME50-9R)
Sex of cell Female
Age at sampling 31Y
Category Spontaneously immortalized cell line
Publications

PubMed=7799951; DOI=10.1128/mcb.15.1.425; PMCID=PMC231985
Shay J.W., Tomlinson G.E., Piatyszek M.A., Gollahon L.S.
Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome.
Mol. Cell. Biol. 15:425-432(1995)

PubMed=17968319; DOI=10.1038/sj.onc.1210886; PMCID=PMC3397201
Pearce V.P., Sherrell J., Lou Z.-J., Kopelovich L., Wright W.E., Shay J.W.
Immortalization of epithelial progenitor cells mediated by resveratrol.
Oncogene 27:2365-2374(2008)

Cross-references
Encyclopedic resources Wikidata; Q117704490
Entry history
Entry creation21-Mar-2023
Last entry update19-Dec-2024
Version number5