ID   SW620(MDR1/3)
AC   CVCL_C7SP
SY   SW620MDR1/3
DR   Wikidata; Q117704902
RX   PubMed=19188929;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:91367; Barasertib-HQPA (AZD1152-HQPA).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0547 ! SW620
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 29-06-23; Version: 2
//
RX   PubMed=19188929; DOI=10.1038/tpj.2008.20;
RA   Guo J., Anderson M.G., Tapang P., Palma J.P., Rodriguez L.E.,
RA   Niquette A.L., Li J.-L., Bouska J.J., Wang G., Semizarov D.,
RA   Albert D.H., Donawho C.K., Glaser K.B., Shah O.J.;
RT   "Identification of genes that confer tumor cell resistance to the
RT   aurora B kinase inhibitor, AZD1152.";
RL   Pharmacogenomics J. 9:90-102(2009).
//