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Cellosaurus LD-1 (CVCL_C7SL)

[Text version]
Cell line name LD-1
Synonyms LD1
Accession CVCL_C7SL
Resource Identification Initiative To cite this cell line use: LD-1 (RRID:CVCL_C7SL)
Comments Genetic integration: Method=Transfection; Gene=MGI; MGI:87986; Akt1.
Genetic integration: Method=Transfection; Gene=MGI; MGI:103262; Yap1.
Transformant: Akt1 and Yap1.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Mouse cholangiocarcinoma (NCIt: C38739)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Category Cancer cell line
Publications

PubMed=33323397; DOI=10.1158/2159-8290.CD-20-0304; PMCID=PMC8102309
Zhang Q.-F., Ma C., Duan Y., Heinrich B., Rosato U., Diggs L.P., Ma L.-C., Roy S., Fu Q., Brown Z.J., Wabitsch S., Thovarai V., Fu J.-Y., Feng D.-C., Ruf B., Cui L.L., Subramanyam V., Frank K.M., Wang S., Kleiner D.E., Ritz T., Rupp C., Gao B., Longerich T., Kroemer A.H.K., Wang X.-W., Ruchirawat M., Korangy F., Schnabl B., Trinchieri G., Greten T.F.
Gut microbiome directs hepatocytes to recruit MDSCs and promote cholangiocarcinoma.
Cancer Discov. 11:1248-1267(2021)

PubMed=34033968; DOI=10.1016/j.jcmgh.2021.05.011; PMCID=PMC8413239
Wabitsch S., Tandon M., Ruf B., Zhang Q.-F., McCallen J.D., McVey J.C., Ma C., Green B.L., Diggs L.P., Heinrich B., Greten T.F.
Anti-PD-1 in combination with trametinib suppresses tumor growth and improves survival of intrahepatic cholangiocarcinoma in mice.
Cell. Mol. Gastroenterol. Hepatol. 12:1166-1178(2021)

Cross-references
Cell line collections (Providers) Kerafast; ECD039-FP
Encyclopedic resources Wikidata; Q117704632
Entry history
Entry creation21-Mar-2023
Last entry update10-Apr-2025
Version number4