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Cellosaurus MCF10A-ERBB2m-10 (CVCL_C7QY)

[Text version]
Cell line name MCF10A-ERBB2m-10
Synonyms MCF10A-ERBB2_type-11; 06M15005
Accession CVCL_C7QY
Resource Identification Initiative To cite this cell line use: MCF10A-ERBB2m-10 (RRID:CVCL_C7QY)
Comments Part of: Fukushima Translational Research Project gene-overexpressing cell lines panel.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3430; ERBB2 (Note=With p.Val842Ile (c.2524G>A)).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Web pages https://www.fmu.ac.jp/home/trc/en/contract-research-provision/human-gene-overexpressing-cell-lines/
Publications

PubMed=30787176; DOI=10.1158/1535-7163.MCT-18-1085
Irie H., Ito K., Fujioka Y., Oguchi K., Fujioka A., Hashimoto A., Ohsawa H., Tanaka K., Funabashi K., Araki H., Kawai Y., Shimamura T., Wadhwa R., Ohkubo S., Matsuo K.
TAS0728, a covalent-binding, HER2-selective kinase inhibitor shows potent antitumor activity in preclinical models.
Mol. Cancer Ther. 18:733-742(2019)

Cross-references
Cell line collections (Providers) CancerTools; 161199
Encyclopedic resources Wikidata; Q117704668
Entry history
Entry creation21-Mar-2023
Last entry update19-Dec-2024
Version number4