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Cellosaurus MCF10A-ERBB2m-5 (CVCL_C7QT)

[Text version]
Cell line name MCF10A-ERBB2m-5
Accession CVCL_C7QT
Resource Identification Initiative To cite this cell line use: MCF10A-ERBB2m-5 (RRID:CVCL_C7QT)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3430; ERBB2 (Note=With p.Ala775_Gly776insTyrValMetAla).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Publications

PubMed=30787176; DOI=10.1158/1535-7163.MCT-18-1085
Irie H., Ito K., Fujioka Y., Oguchi K., Fujioka A., Hashimoto A., Ohsawa H., Tanaka K., Funabashi K., Araki H., Kawai Y., Shimamura T., Wadhwa R., Ohkubo S., Matsuo K.
TAS0728, a covalent-binding, HER2-selective kinase inhibitor shows potent antitumor activity in preclinical models.
Mol. Cancer Ther. 18:733-742(2019)

Cross-references
Cell line collections (Providers) CancerTools; 161194
Encyclopedic resources Wikidata; Q117704676
Entry history
Entry creation21-Mar-2023
Last entry update10-Sep-2024
Version number3