ID   W.Hb12
AC   CVCL_C7PV
SY   Hb12
DR   Wikidata; Q117704964
RX   PubMed=8022822;
RX   PubMed=9371519;
RX   PubMed=12203227;
RX   PubMed=15702245;
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:990; BCL2.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
CC   Breed/subspecies: BALB/c.
DI   NCIt; C198577; Mouse thymoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_3950 ! WEHI-7.2
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 19-12-24; Version: 4
//
RX   PubMed=8022822; DOI=10.1073/pnas.91.14.6569; PMCID=PMC44244;
RA   Lam M., Dubyak G.R., Chen L., Nunez G., Miesfeld R.L., Distelhorst C.W.;
RT   "Evidence that BCL-2 represses apoptosis by regulating endoplasmic
RT   reticulum-associated Ca2+ fluxes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:6569-6573(1994).
//
RX   PubMed=9371519;
RA   Baker A., Payne C.M., Briehl M.M., Powis G.;
RT   "Thioredoxin, a gene found overexpressed in human cancer, inhibits
RT   apoptosis in vitro and in vivo.";
RL   Cancer Res. 57:5162-5167(1997).
//
RX   PubMed=12203227; DOI=10.1002/nbm.790;
RA   Lutz N.W., Tome M.E., Aiken N.R., Briehl M.M.;
RT   "Changes in phosphate metabolism in thymoma cells suggest mechanisms
RT   for resistance to dexamethasone-induced apoptosis. A 31P NMR
RT   spectroscopic study of cell extracts.";
RL   NMR Biomed. 15:356-366(2002).
//
RX   PubMed=15702245; DOI=10.3892/ijmm.15.3.497;
RA   Tome M.E., Briehl M.M., Lutz N.W.;
RT   "Increasing the antioxidant defense in WEHI7.2 cells results in a more
RT   tumor-like metabolic profile.";
RL   Int. J. Mol. Med. 15:497-501(2005).
//