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Cellosaurus RT112 CP1.5 K2 (CVCL_C7JZ)

[Text version]
Cell line name RT112 CP1.5 K2
Synonyms K2
Accession CVCL_C7JZ
Resource Identification Initiative To cite this cell line use: RT112 CP1.5 K2 (RRID:CVCL_C7JZ)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Gene fusion; HGNC; 3690; FGFR3 + HGNC; 11524; TACC3; Name(s)=FGFR3-TACC3 (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser183Ter (c.548C>G); ClinVar=VCV000634701; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C7JU (RT112 CP1.5)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=10422815; DOI=10.1007/s002400050103
Siegsmund M.J., Marx C., Seemann O., Schummer B., Steidler A., Toktomambetova L., Kohrmann K.-U., Rassweiler J., Alken P.
Cisplatin-resistant bladder carcinoma cells: enhanced expression of metallothioneins.
Urol. Res. 27:157-163(1999)

Cross-references
Encyclopedic resources Wikidata; Q117704827
Entry history
Entry creation21-Mar-2023
Last entry update29-Jun-2023
Version number2