Cellosaurus cell line K562-mb15 (CVCL

Cellosaurus K562-mb15 (CVCL_C7IL)

[Text version]

Cell line name

K562-mb15

Accession

CVCL_C7IL

Resource Identification Initiative

To cite this cell line use: K562-mb15 (RRID:CVCL_C7IL)

Comments

Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 5977; IL15 (Note=Membrane bound, contains the signal peptide of CD8A, the mature part of IL15 and the transmembrane domain of CD8A).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).

Disease

Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0004 (K-562)
Children:

CVCL_C7IM (K562-mb15-41BBL)

Sex of cell

Female

Age at sampling

53Y