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Cellosaurus 67-2 (CVCL_C7I4)

[Text version]
Cell line name 67-2
Accession CVCL_C7I4
Resource Identification Initiative To cite this cell line use: 67-2 (RRID:CVCL_C7I4)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized pepinemab (VX15/2503) therapeutic antibody which is used in clinical trials for the treatment of a number of neuroinflammatory/neurodegenerative diseases.
Monoclonal antibody isotype: IgG1.
Monoclonal antibody target: UniProtKB; Q92854; Human SEMA4D/CD100 (Note=Also reacts with mouse).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=26431358; DOI=10.1080/19420862.2015.1102813; PMCID=PMC4966508
Fisher T.L., Reilly C.A., Winter L.A., Pandina T., Jonason A., Scrivens M., Balch L., Bussler H., Torno S., Seils J., Mueller L., Huang H., Klimatcheva E., Howell A., Kirk R., Evans E.E., Paris M., Leonard J.E., Smith E.S., Zauderer M.
Generation and preclinical characterization of an antibody specific for SEMA4D.
MAbs 8:150-162(2016)

Cross-references
Encyclopedic resources Wikidata; Q123030309
Entry history
Entry creation21-Mar-2023
Last entry update30-Jan-2024
Version number2