Cellosaurus cell line DKFZ-BT308 (CVCL

Cellosaurus DKFZ-BT308 (CVCL_C7GU)

Cross-references
Cell line name	DKFZ-BT308
Accession	CVCL_C7GU
Resource Identification Initiative	To cite this cell line use: DKFZ-BT308 (RRID:CVCL_C7GU)
Comments	Characteristics: Transduced with a doxycycline-inducible system coding for SV40 large T antigen and GFP (PubMed=35977048). Senescence: Withdrawal of doxycyclin leads to senescence (PubMed=35977048). Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations	Gene fusion; HGNC; HGNC:1097; BRAF + HGNC; HGNC:22219; KIAA1549; Name(s)=KIAA1549-BRAF (PubMed=35977048).
Disease	Pilocytic astrocytoma (NCIt: C4047) Pilocytic astrocytoma (ORDO: Orphanet_251612)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	5Y
Category	Cancer cell line
Publications	PubMed=35977048; DOI=10.1093/neuonc/noac199; PMCID=PMC10076946 Selt F., Sigaud R., Valinciute G., Sievers P., Zaman J., Alco C., Schmid S., Peterziel H., Tsai J.W., Guiho R., Martinez-Barbera J.P., Pusch S., Deng J., Zhai Y.-F., van Tilburg C.M., Schuhmann M.U., El Damaty A., Bandopadhayay P., Herold-Mende C., von Deimling A., Pfister S.M., Montero J., Capper D., Oehme I., Sahm F., Jones D.T.W., Witt O., Milde T. BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma. Neuro-oncol. 25:735-747(2023)
Encyclopedic resources	Wikidata; Q117704285
Entry history
Entry creation	21-Mar-2023
Last entry update	19-Dec-2024
Version number	4