ID   CHORC5 DeltaP-gp A1
AC   CVCL_C7GL
DR   Wikidata; Q117704242
RX   PubMed=35381425;
CC   Characteristics: Shows complete reversal of the resistance to both colchicine and doxorubicin which exist in the parental cell line (PubMed=35381425).
CC   Knockout cell: Method=CRISPR/Cas9; UniProtKB; P21448; Abcb1.
CC   Selected for resistance to: ChEBI; CHEBI:23359; Colchicine.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D266 ! CHO-CHRC5
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 21-03-23; Last updated: 30-01-24; Version: 3
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RX   PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148;
RA   Limniatis G., Georges E.;
RT   "Knockout of P-glycoprotein abolish the collateral sensitivity of
RT   CHO(R)C5 multidrug resistant cells.";
RL   Biochem. Biophys. Res. Commun. 608:23-29(2022).
//