| Cell line name |
A375-NTP-R |
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| Accession |
CVCL_C7GI |
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| Resource Identification Initiative |
To cite this cell line use: A375-NTP-R (RRID:CVCL_C7GI) |
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| Comments |
Population: Caucasian.
Selected for resistance to: NCIt; C192869; Non-thermal plasma.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. |
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| Sequence variations |
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
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| Disease |
Amelanotic melanoma (NCIt: C3802) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0132 (A-375) |
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| Sex of cell |
Female |
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| Age at sampling |
54Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=36630862; DOI=10.1016/j.drup.2022.100914
Lin A., Sahun M., Biscop E., Verswyvel H., De Waele J., De Backer J., Theys C., Cuypers B., Laukens K., Vanden Berghe W., Smits E., Bogaerts A.
Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma.
Drug Resist. Updat. 67:100914.1-100914.16(2023) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q123030358
|
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| Entry history |
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| Entry creation | 21-Mar-2023 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 4 |
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