ID   STC-1 pGIP/Neo
AC   CVCL_C6ND
SY   pGIP/Neo STC-1; pGIP/Neo
DR   Wikidata; Q116050577
RX   PubMed=12124779;
RX   PubMed=22768997;
RX   PubMed=28870797;
CC   Characteristics: Expression of the neo gene is driven by a rat GIP promoter (PubMed=12124779).
CC   Characteristics: Compared to parent cell line secrete 3-6 times more GIP and substantially less CCK and PYY (PubMed=22768997).
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P68835; Murine polyomavirus (strain A2) (MPyV) small T antigen (PyST).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 10636; Murine polyomavirus (strain A2) (MPyV).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Small intestine, duodenum; UBERON=UBERON_0002114.
CC   Breed/subspecies: C57BL/6J double transgenic RIP1Tag2/Rip2pyST1.
DI   NCIt; C22150; Neuroendocrine adenoma of the mouse intestinal tract
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_J405 ! STC-1
SX   Sex unspecified
AG   10-13W
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 10-09-24; Version: 5
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RX   PubMed=12124779; DOI=10.1002/jcp.10139;
RA   Ramshur E.B., Rull T.R., Wice B.M.;
RT   "Novel insulin/GIP co-producing cell lines provide unexpected insights
RT   into gut K-cell function in vivo.";
RL   J. Cell. Physiol. 192:339-350(2002).
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RX   PubMed=22768997; DOI=10.1016/j.metabol.2012.05.017;
RA   Hand K.V., Giblin L., Green B.D.;
RT   "Hormone profiling in a novel enteroendocrine cell line pGIP/neo:
RT   STC-1.";
RL   Metabolism 61:1683-1686(2012).
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RX   PubMed=28870797; DOI=10.1016/j.peptides.2017.08.010;
RA   Gillespie A.L., Pan X.-B., Marco-Ramell A., Meharg C., Green B.D.;
RT   "Detailed characterisation of STC-1 cells and the pGIP/Neo sub-clone
RT   suggests the incretin hormones are translationally regulated.";
RL   Peptides 96:20-30(2017).
//