ID   JN-DSRCT-SLFN11-KO
AC   CVCL_C6N7
DR   Wikidata; Q116049602
RX   PubMed=34413129;
CC   Population: Japanese.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:26633; SLFN11.
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:12796; WT1; Name(s)=EWSR1-WT1, EWS-WT1; Note=EWSR1 Ex10-WT1 Ex8 fusion (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2348; CREBBP; Simple; p.Arg1443Alafs*11; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Arg367Ter (c.1099C>T); ClinVar=VCV000016626; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Arg621Ser (c.1861C>A); ClinVar=VCV000135120; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C27372; Childhood desmoplastic small round cell tumor
DI   ORDO; Orphanet_83469; Desmoplastic small round cell tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9W68 ! JN-DSRCT-1
SX   Male
AG   7Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 19-12-24; Version: 4
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RX   PubMed=34413129; DOI=10.1158/1535-7163.MCT-21-0089; PMCID=PMC8571037;
RA   Gartrell J., Mellado-Largarde M., Clay M.R., Bahrami A., Sahr N.A.,
RA   Sykes A.D., Blankenship K., Hoffmann L., Xie J., Cho H.P., Twarog N.,
RA   Connelly M., Yan K.-K., Yu J.-Y., Porter S.N., Pruett-Miller S.M.,
RA   Neale G., Tinkle C.L., Federico S.M., Stewart E.A., Shelat A.A.;
RT   "SLFN11 is widely expressed in pediatric sarcoma and induces variable
RT   sensitization to replicative stress caused by DNA-damaging agents.";
RL   Mol. Cancer Ther. 20:2151-2165(2021).
//