ID   FE1
AC   CVCL_C6KP
DR   ArrayExpress; E-MEXP-1054
DR   Wikidata; Q116049010
RX   PubMed=14556224;
RX   PubMed=19406224;
RX   PubMed=28843037;
CC   Characteristics: Can be employed for in vitro mutagenicity assessment. Established from a MutaMouse that contains 40 copies of the lacZ reporter gene in a single locus on chromosome 3.
CC   Doubling time: 18.7 +- 1.2 hours (PubMed=14556224).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Epithelial cell; CL=CL_0000066.
CC   Breed/subspecies: MutaMouse 40.6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 15-12-22; Last updated: 10-09-24; Version: 4
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RX   PubMed=14556224; DOI=10.1002/em.10185;
RA   White P.A., Douglas G.R., Gingerich J., Parfett C.L.J., Shwed P.,
RA   Seligy V., Soper L., Berndt-Weis M.L., Bayley J., Wagner S., Pound K.,
RA   Blakey D.H.;
RT   "Development and characterization of a stable epithelial cell line
RT   from Muta Mouse lung.";
RL   Environ. Mol. Mutagen. 42:166-184(2003).
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RX   PubMed=19406224; DOI=10.1016/j.tiv.2009.04.008;
RA   Berndt-Weis M.L., Kauri L.M., Williams A., White P.A., Douglas G.,
RA   Yauk C.;
RT   "Global transcriptional characterization of a mouse pulmonary
RT   epithelial cell line for use in genetic toxicology.";
RL   Toxicol. In Vitro 23:816-833(2009).
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RX   PubMed=28843037; DOI=10.1002/em.22125;
RA   Maertens R.M., Long A.S., White P.A.;
RT   "Performance of the in vitro transgene mutation assay in MutaMouse FE1
RT   cells: evaluation of nine misleading ('false') positive chemicals.";
RL   Environ. Mol. Mutagen. 58:582-591(2017).
//