| Cell line name |
SupT1-CIITA |
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| Synonyms |
SupT1-CIITA B5; SupT1.CIITA |
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| Accession |
CVCL_C6JB |
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| Resource Identification Initiative |
To cite this cell line use: SupT1-CIITA (RRID:CVCL_C6JB) |
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| Comments |
Population: Caucasian.
Virology: Has an enhanced susceptibility to infection by HIV-1 (PubMed=21041720).
Virology: Susceptible to infection by herpesvirus 6B (HHV-6B) strain Z29 (PubMed=31020640).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7067; CIITA.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Proteomics; HLA class II peptidome.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
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| HLA typing |
Source: PubMed=31020640
| Class II | | HLA-DR | DRB1*03:01,13:01 | | DRB3*01:01,02:02 |
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| Disease |
Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1714 (SUP-T1) |
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| Sex of cell |
Male |
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| Age at sampling |
8Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=21041720; DOI=10.4049/jimmunol.1000830
Porter K.A., Kelley L.N., Nekorchuk M.D., Jones J.H., Hahn A.B., de Noronha C.M.C., Harton J.A., Duus K.M.
CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion.
J. Immunol. 185:6480-6488(2010) PubMed=31020640; DOI=10.1002/eji.201948126
Becerra-Artiles A., Cruz J., Leszyk J.D., Sidney J., Sette A., Shaffer S.A., Stern L.J.
Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.
Eur. J. Immunol. 49:1167-1185(2019) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q116050582
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| Proteomic databases |
PRIDE; PXD013015
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| Entry history |
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| Entry creation | 15-Dec-2022 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 7 |
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