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Cellosaurus SupT1-CIITA (CVCL_C6JB)

[Text version]
Cell line name SupT1-CIITA
Synonyms SupT1-CIITA B5; SupT1.CIITA
Accession CVCL_C6JB
Resource Identification Initiative To cite this cell line use: SupT1-CIITA (RRID:CVCL_C6JB)
Comments Population: Caucasian.
Virology: Has an enhanced susceptibility to infection by HIV-1 (PubMed=21041720).
Virology: Susceptible to infection by herpesvirus 6B (HHV-6B) strain Z29 (PubMed=31020640).
Transfected with: HGNC; 7067; CIITA.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Omics: HLA class II peptidome analysis by proteomics.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
HLA typing Source: PubMed=31020640
Class II
HLA-DRDRB1*03:01,13:01
DRB3*01:01,02:02
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1714 (SUP-T1)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=21041720; DOI=10.4049/jimmunol.1000830
Porter K.A., Kelley L.N., Nekorchuk M.D., Jones J.H., Hahn A.B., de Noronha C.M.C., Harton J.A., Duus K.M.
CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion.
J. Immunol. 185:6480-6488(2010)

PubMed=31020640; DOI=10.1002/eji.201948126
Becerra-Artiles A., Cruz J., Leszyk J.D., Sidney J., Sette A., Shaffer S.A., Stern L.J.
Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.
Eur. J. Immunol. 49:1167-1185(2019)

Cross-references
Encyclopedic resources Wikidata; Q116050582
Proteomic databases PRIDE; PXD013015
Entry history
Entry creation15-Dec-2022
Last entry update05-Oct-2023
Version number4