ID   INT-MEL-17
AC   CVCL_C680
SY   Me4405; ME4405; ME-4405; ME 4405
DR   BTO; BTO_0005716
DR   cancercelllines; CVCL_C680
DR   Cosmic; 889008
DR   Cosmic; 929202
DR   GEO; GSM1403049
DR   GEO; GSM1403050
DR   GEO; GSM1403051
DR   GEO; GSM1403052
DR   GEO; GSM1403053
DR   GEO; GSM1403054
DR   Wikidata; Q54897764
RX   DOI=10.13130/grazia-giulia_phd2016-02-18;
RX   DOI=10.1007/0-306-46872-7_16;
RX   PubMed=7520026;
RX   PubMed=8459226;
RX   PubMed=8980186;
RX   PubMed=9725211;
RX   PubMed=10338330;
RX   PubMed=15048078;
RX   PubMed=22383533;
RX   PubMed=22553342;
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (PubMed=15048078; PubMed=22383533).
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_C688 ! LCL4405
SX   Female
AG   83Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 18
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RX   DOI=10.13130/grazia-giulia_phd2016-02-18;
RA   Grazia G.;
RT   "Co-targeting of oncogenic and death receptors pathways in human
RT   melanoma: pre-clinical rationale for a pro-apoptotic and anti-angiogenic
RT   strategy.";
RL   Thesis PhD (2015); Universita degli studi di Milano; Milano; Italy.
//
RX   DOI=10.1007/0-306-46872-7_16;
RA   Anichini A., Mortarini R., Vegetti C., Molla A., Borri A., Parmiani G.;
RT   "Melanoma: the Milan melanoma cell lines.";
RL   (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.283-292; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=7520026; DOI=10.1002/ijc.2910580413;
RA   Hersey P., Si Z.-Y., Smith M.J., Thomas W.D.;
RT   "Expression of the co-stimulatory molecule B7 on melanoma cells.";
RL   Int. J. Cancer 58:527-532(1994).
//
RX   PubMed=8459226; DOI=10.1084/jem.177.4.989; PMCID=PMC2190978;
RA   Anichini A., Maccalli C., Mortarini R., Salvi S., Mazzocchi A.,
RA   Squarcina P., Herlyn M., Parmiani G.;
RT   "Melanoma cells and normal melanocytes share antigens recognized by
RT   HLA-A2-restricted cytotoxic T cell clones from melanoma patients.";
RL   J. Exp. Med. 177:989-998(1993).
//
RX   PubMed=8980186; DOI=10.1002/(SICI)1097-0215(19961211)68:6<795::AID-IJC18>3.0.CO;2-#;
RA   Thomas W.D., Smith M.J., Si Z.-Y., Hersey P.;
RT   "Expression of the co-stimulatory molecule CD40 on melanoma cells.";
RL   Int. J. Cancer 68:795-801(1996).
//
RX   PubMed=9725211; DOI=10.4049/jimmunol.161.5.2195;
RA   Thomas W.D., Hersey P.;
RT   "TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in
RT   Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of
RT   target cells.";
RL   J. Immunol. 161:2195-2200(1998).
//
RX   PubMed=10338330; DOI=10.1097/00008390-199902000-00003;
RA   Rizos H., Darmanian A.P., Indsto J.O., Shannon J.A., Kefford R.F.,
RA   Mann G.J.;
RT   "Multiple abnormalities of the p16INK4a-pRb regulatory pathway in
RT   cultured melanoma cells.";
RL   Melanoma Res. 9:10-19(1999).
//
RX   PubMed=15048078; DOI=10.1038/sj.onc.1207563;
RA   Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M.,
RA   Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L.,
RA   Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G.,
RA   Meltzer P.S., Ringner M., Hayward N.K.;
RT   "Microarray expression profiling in melanoma reveals a BRAF mutation
RT   signature.";
RL   Oncogene 23:4060-4067(2004).
//
RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V.,
RA   Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M.,
RA   Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.;
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
//
RX   PubMed=22553342; DOI=10.1158/1078-0432.CCR-11-2232; PMCID=PMC3426233;
RA   Tassi E., Zanon M., Vegetti C., Molla A., Bersani I., Perotti V.,
RA   Pennati M., Zaffaroni N., Milella M., Ferrone S., Carlo-Stella C.,
RA   Gianni A.M., Mortarini R., Anichini A.;
RT   "Role of Apollon in human melanoma resistance to antitumor agents that
RT   activate the intrinsic or the extrinsic apoptosis pathways.";
RL   Clin. Cancer Res. 18:3316-3327(2012).
//