Cellosaurus cell line UKRV-Mel-22a (CVCL

Cellosaurus UKRV-Mel-22a (CVCL_C661)

[Text version]

Cell line name

UKRV-Mel-22a

Accession

CVCL_C661

Resource Identification Initiative

To cite this cell line use: UKRV-Mel-22a (RRID:CVCL_C661)

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=23851445).
Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503; PubMed=23851445).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_C662 ! UKRV-Mel-22b

Sex of cell

Male

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-182

Markers:

Amelogenin	X,Y
CSF1PO	11,12
D3S1358	15,16
D5S818	11,12
D7S820	9
D13S317	9,12
FGA	21,24
TH01	9.3
TPOX	8,11
vWA	18

Publications

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_C661
ESTDAB; ESTDAB-182

Encyclopedic resources

Wikidata; Q54990618

Polymorphism and mutation databases

Cosmic; 1846717
Cosmic; 2163860
Cosmic; 2686530

Entry history

Entry creation

22-Oct-2012

Last entry update

19-Dec-2024

Version number