ID   FM78
AC   CVCL_C606
SY   FM-78
DR   cancercelllines; CVCL_C606
DR   Cosmic; 1047677
DR   Cosmic; 2163775
DR   ECACC; 13012420
DR   ESTDAB; ESTDAB-023
DR   GEO; GSM156029
DR   IARC_TP53; 26103
DR   Progenetix; CVCL_C606
DR   Wikidata; Q54835064
RX   PubMed=9288767;
RX   PubMed=15592718;
RX   PubMed=17260012;
RX   PubMed=23851445;
CC   HLA typing: A*31:01:02,03:01; B*15:01:01:01,27:04; C*02:02:02,03:03; DPB1*04:01; DQB1*03:01:01,05:01:01; DRB1*01:01:01,04:01:01 (PubMed=15592718).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=17260012).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val272Gly (c.815T>G); ClinVar=VCV000233323; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
CC   Omics: Variations; Array-based CGH.
ST   Source(s): ECACC=13012420; ESTDAB=ESTDAB-023
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8,11
ST   D16S539: 12
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 10
ST   FGA: 22,24
ST   TH01: 9,9.3
ST   TPOX: 8,11
ST   vWA: 15,16
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 14-08-25; Version: 22
//
RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl, Christina
RA   Christensen, Claus
RA   Jonsson, Goran
RA   Lorentzen, Anders
RA   Skjodt, Mette Louise
RA   Borg, Ake
RA   Pawelec, Graham
RA   Guldberg, Per
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//
RX   PubMed=9288767;
RA   Guldberg, Per
RA   thor Straten, Per
RA   Birck, Anette
RA   Ahrenkiel, Vibeke
RA   Kirkin, Alexei F.
RA   Zeuthen, Jesper
RT   "Disruption of the MMAC1/PTEN gene by deletion or mutation is a
RT   frequent event in malignant melanoma.";
RL   Cancer Res. 57:3660-3663(1997).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez, Teresa
RA   Mendez, Rosa
RA   Roberts, Chrissy H.
RA   Ruiz-Cabello Osuna, Francisco
RA   Dodi, I. Anthony
RA   Lopez-Nevot, Miguel Angel
RA   Paco, Laura
RA   Maleno, Isabel
RA   Marsh, Steven G.E.
RA   Pawelec, Graham
RA   Garrido, Federico
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=17260012; DOI=10.1038/sj.onc.1210252;
RA   Jonsson, Goran
RA   Dahl, Christina
RA   Staaf, Johan
RA   Sandberg, Troy
RA   Bendahl, Par-Ola
RA   Ringner, Markus
RA   Guldberg, Per
RA   Borg, Ake
RT   "Genomic profiling of malignant melanoma using tiling-resolution
RT   arrayCGH.";
RL   Oncogene 26:4738-4748(2007).
//