ID   FM70
AC   CVCL_C601
SY   FM-70
DR   cancercelllines; CVCL_C601
DR   Cosmic; 808553
DR   Cosmic; 851408
DR   Cosmic; 2163773
DR   ECACC; 13012491
DR   ESTDAB; ESTDAB-020
DR   Wikidata; Q54835059
RX   PubMed=8968104;
RX   PubMed=9288767;
RX   PubMed=19340423;
RX   PubMed=23851445;
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=23851445).
CC   Sequence variation: Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (PubMed=9288767; PubMed=23851445).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23851445).
ST   Source(s): ECACC=13012491; ESTDAB=ESTDAB-020
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12,13
ST   D16S539: 11
ST   D3S1358: 14,18
ST   D5S818: 11
ST   D7S820: 10,11
ST   FGA: 22,24
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 18
//
RX   PubMed=8968104;
RA   Bartkova J., Lukas J., Guldberg P., Alsner J., Kirkin A.F.,
RA   Zeuthen J., Bartek J.;
RT   "The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently
RT   altered in melanoma pathogenesis.";
RL   Cancer Res. 56:5475-5483(1996).
//
RX   PubMed=9288767;
RA   Guldberg P., thor Straten P., Birck A., Ahrenkiel V., Kirkin A.F.,
RA   Zeuthen J.;
RT   "Disruption of the MMAC1/PTEN gene by deletion or mutation is a
RT   frequent event in malignant melanoma.";
RL   Cancer Res. 57:3660-3663(1997).
//
RX   PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131;
RA   Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T.,
RA   Ruiz-Cabello Osuna F., Garrido F., Garcia-Lora A.;
RT   "HLA and melanoma: multiple alterations in HLA class I and II
RT   expression in human melanoma cell lines from ESTDAB cell bank.";
RL   Cancer Immunol. Immunother. 58:1507-1515(2009).
//
RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L.,
RA   Borg A., Pawelec G., Guldberg P.;
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//