ID   MZ2-MEL.43
AC   CVCL_C5U6
DR   Wikidata; Q116049847
RX   PubMed=2529220;
RX   PubMed=8566071;
RX   PubMed=8642259;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9829; RAF1; Simple; p.Ser257Leu (c.770C>T); ClinVar=VCV000013957; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from site: Metastatic; Abdomen; UBERON=UBERON_0000916.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C5U4 ! MZ2-MEL.3.0
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 19-12-24; Version: 5
//
RX   PubMed=8566071; DOI=10.1002/eji.1830260135;
RA   Brichard, Vincent G.
RA   Herman, Jean
RA   Van Pel, Aline
RA   Wildmann, Claude
RA   Gaugler, Beatrice
RA   Wolfel, Thomas
RA   Boon, Thierry
RA   Lethe, Bernard
RT   "A tyrosinase nonapeptide presented by HLA-B44 is recognized on a
RT   human melanoma by autologous cytolytic T lymphocytes.";
RL   Eur. J. Immunol. 26:224-230(1996).
//
RX   PubMed=8642259; DOI=10.1084/jem.183.3.1173; PMCID=PMC2192325;
RA   Guilloux, Yannik
RA   Lucas, Sophie
RA   Brichard, Vincent G.
RA   Van Pel, Aline
RA   Viret, Christophe
RA   De Plaen, Etienne
RA   Brasseur, Francis
RA   Lethe, Bernard
RA   Jotereau, Francine
RA   Boon, Thierry
RT   "A peptide recognized by human cytolytic T lymphocytes on HLA-A2
RT   melanomas is encoded by an intron sequence of the
RT   N-acetylglucosaminyltransferase V gene.";
RL   J. Exp. Med. 183:1173-1183(1996).
//
RX   PubMed=2529220; DOI=10.1002/ijc.2910440413;
RA   van den Eynde, Benoit J.
RA   Hainaut, Philippe
RA   Herin, Michel
RA   Knuth, Alexander
RA   Lemoine, Carine
RA   Weynants, Patrick
RA   van der Bruggen, Pierre
RA   Fauchet, Rene
RA   Boon, Thierry
RT   "Presence on a human melanoma of multiple antigens recognized by
RT   autologous CTL.";
RL   Int. J. Cancer 44:634-640(1989).
//