ID   MZ2-MEL.43
AC   CVCL_C5U6
DR   Wikidata; Q116049847
RX   PubMed=2529220;
RX   PubMed=8566071;
RX   PubMed=8642259;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9829; RAF1; Simple; p.Ser257Leu (c.770C>T); ClinVar=VCV000013957; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from site: Metastatic; Abdomen; UBERON=UBERON_0000916.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C5U4 ! MZ2-MEL.3.0
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 19-12-24; Version: 5
//
RX   PubMed=2529220; DOI=10.1002/ijc.2910440413;
RA   van den Eynde B.J., Hainaut P., Herin M., Knuth A., Lemoine C.,
RA   Weynants P., van der Bruggen P., Fauchet R., Boon T.;
RT   "Presence on a human melanoma of multiple antigens recognized by
RT   autologous CTL.";
RL   Int. J. Cancer 44:634-640(1989).
//
RX   PubMed=8566071; DOI=10.1002/eji.1830260135;
RA   Brichard V.G., Herman J., Van Pel A., Wildmann C., Gaugler B.,
RA   Wolfel T., Boon T., Lethe B.;
RT   "A tyrosinase nonapeptide presented by HLA-B44 is recognized on a
RT   human melanoma by autologous cytolytic T lymphocytes.";
RL   Eur. J. Immunol. 26:224-230(1996).
//
RX   PubMed=8642259; DOI=10.1084/jem.183.3.1173; PMCID=PMC2192325;
RA   Guilloux Y., Lucas S., Brichard V.G., Van Pel A., Viret C.,
RA   De Plaen E., Brasseur F., Lethe B., Jotereau F., Boon T.;
RT   "A peptide recognized by human cytolytic T lymphocytes on HLA-A2
RT   melanomas is encoded by an intron sequence of the
RT   N-acetylglucosaminyltransferase V gene.";
RL   J. Exp. Med. 183:1173-1183(1996).
//