ID   STSW-01-LUC
AC   CVCL_C5TY
DR   Wikidata; Q116050579
RX   PubMed=35732500;
CC   Sequence variation: Gene deletion; HGNC; HGNC:7773; NF2; Simple; Zygosity=Heterozygous (PubMed=35732500).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11103; SMARCB1; Simple; Zygosity=Heterozygous (PubMed=35732500).
CC   Sequence variation: Mutation; HGNC; HGNC:7773; NF2; Simple; p.Trp60Cysfs*62 (c.180delG); Zygosity=Heterozygous; Note=Germline (PubMed=35732500).
CC   Sequence variation: Mutation; HGNC; HGNC:11103; SMARCB1; Simple; p.Glu122Ter (c.364G>T); ClinVar=VCV001076272; Zygosity=Heterozygous; Note=Germline (PubMed=35732500).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
CC   Cell type: Schwann cell; CL=CL_0002573.
DI   NCIt; C6557; Schwannomatosis
DI   ORDO; Orphanet_93921; Schwannomatosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C5TX ! STSW-01
SX   Sex unspecified
AG   32Y
CA   Telomerase immortalized cell line
DT   Created: 15-12-22; Last updated: 19-12-24; Version: 5
//
RX   PubMed=35732500; DOI=10.1101/mcs.a006178; PMCID=PMC9235848;
RA   Allaf A., Victoria B., Rosario R., Misztal C., Gultekin S.H.,
RA   Dinh C.T., Fernandez-Valle C.;
RT   "WP1066 induces cell death in a schwannomatosis patient-derived
RT   schwannoma cell line.";
RL   Cold Spring Harb. Mol. Case Stud. 8:a006178.1-a006178.16(2022).
//