Cellosaurus cell line SNU-2535LR (CVCL

Cross-references
Cell line name	SNU-2535LR
Accession	CVCL_C5TR
Resource Identification Initiative	To cite this cell line use: SNU-2535LR (RRID:CVCL_C5TR)
Comments	Population: Korean. Characteristics: Resistant to crizotinib (from parent cell line). Characteristics: Has lost the ALK p.Gly1269Ala mutation of the parent cell line (PubMed=35852680). Selected for resistance to: ChEBI; CHEBI_143117; Lorlatinib (Lorbrena; Lorviqua; PF-6463922). Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK (PubMed=35852680). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Val (c.854A>T); ClinVar=VCV000012384; Zygosity=Homozygous (PubMed=35852680).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_R756 (SNU-2535)
Sex of cell	Female
Age at sampling	57Y
Category	Cancer cell line
Publications	PubMed=35852680; DOI=10.1007/s12094-022-02884-x Xie B., Qiu Y., Zhou J., Du D., Ma H.-C., Ji J.-P., Zhu L.-Q., Zhang W.-M. Establishment of an acquired lorlatinib-resistant cell line of non-small cell lung cancer and its mediated resistance mechanism. Clin. Transl. Oncol. 24:2231-2240(2022)
Encyclopedic resources	Wikidata; Q116050519
Entry history
Entry creation	15-Dec-2022
Last entry update	19-Dec-2024
Version number	4