Cellosaurus logo
expasy logo

Cellosaurus SNU-2535LR (CVCL_C5TR)

[Text version]
Cell line name SNU-2535LR
Accession CVCL_C5TR
Resource Identification Initiative To cite this cell line use: SNU-2535LR (RRID:CVCL_C5TR)
Comments Population: Korean.
Characteristics: Resistant to crizotinib (from parent cell line).
Characteristics: Has lost the ALK p.Gly1269Ala mutation of the parent cell line (PubMed=35852680).
Selected for resistance to: ChEBI; CHEBI:143117; Lorlatinib (Lorbrena; Lorviqua; PF-6463922).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 427; ALK + HGNC; 1316; EML4; Name(s)=EML4-ALK (PubMed=35852680).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu285Val (c.854A>T); ClinVar=VCV000012384; Zygosity=Homozygous (PubMed=35852680).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_R756 (SNU-2535)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=35852680; DOI=10.1007/s12094-022-02884-x
Xie B., Qiu Y., Zhou J., Du D., Ma H.-C., Ji J.-P., Zhu L.-Q., Zhang W.-M.
Establishment of an acquired lorlatinib-resistant cell line of non-small cell lung cancer and its mediated resistance mechanism.
Clin. Transl. Oncol. 24:2231-2240(2022)

Cross-references
Encyclopedic resources Wikidata; Q116050519
Entry history
Entry creation15-Dec-2022
Last entry update29-Jun-2023
Version number3