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Cellosaurus A549/TR (CVCL_C5S0)

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Cell line name A549/TR
Accession CVCL_C5S0
Resource Identification Initiative To cite this cell line use: A549/TR (RRID:CVCL_C5S0)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=26498137; DOI=10.3892/ijo.2015.3216
Kyung-Chan Kim, Suk-Hwan Baek, Chuhee Lee;
Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells.
Int. J. Oncol. 47:2296-2303(2015)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4483127
ChEMBL-Targets; CHEMBL4483226
Encyclopedic resources Wikidata; Q116048464
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number4