ID   HepG2-CD81
AC   CVCL_C5RN
SY   HepG2/CD81+
DR   ChEMBL-Cells; CHEMBL4543855
DR   ChEMBL-Targets; CHEMBL4543887
DR   Wikidata; Q116049312
RX   PubMed=12913001;
RX   PubMed=16819966;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 1701; CD81.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 29-06-23; Version: 3
//
RX   PubMed=12913001; DOI=10.1074/jbc.M305289200;
RA   Bartosch B., Vitelli A., Granier C., Goujon C., Dubuisson J.,
RA   Pascale S., Scarselli E., Cortese R., Nicosia A., Cosset F.-L.;
RT   "Cell entry of hepatitis C virus requires a set of co-receptors that
RT   include the CD81 tetraspanin and the SR-B1 scavenger receptor.";
RL   J. Biol. Chem. 278:41624-41630(2003).
//
RX   PubMed=16819966; DOI=10.1111/j.1462-5822.2006.00697.x;
RA   Silvie O., Greco C., Franetich J.-F., Dubart-Kupperschmitt A.,
RA   Hannoun L., van Gemert G.-J., Sauerwein R.W., Levy S., Boucheix C.,
RA   Rubinstein E., Mazier D.;
RT   "Expression of human CD81 differently affects host cell susceptibility
RT   to malaria sporozoites depending on the Plasmodium species.";
RL   Cell. Microbiol. 8:1134-1146(2006).
//