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Cellosaurus NL20T (CVCL_C5B5)

[Text version]
Cell line name NL20T
Accession CVCL_C5B5
Resource Identification Initiative To cite this cell line use: NL20T (RRID:CVCL_C5B5)
Comments Population: Caucasian.
Characteristics: Forms very slowly growing tumors in nude mice. Established from a spontaneously occurring subcutaneous tumor in an athymic nude mouse inoculated with the parent cell line (PubMed=9216860).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3756 (NL20)
Children:
CVCL_3757 (NL20T-A)CVCL_C5B6 (NL20T-B)
Sex of cell Female
Age at sampling 20Y
Category Transformed cell line
Publications

PubMed=8521416
Schiller J.H., Bittner G.N.
Loss of the tumorigenic phenotype with in vitro, but not in vivo, passaging of a novel series of human bronchial epithelial cell lines: possible role of an alpha5/beta1-integrin-fibronectin interaction.
Cancer Res. 55:6215-6221(1995)

PubMed=9216860; DOI=10.1159/000227713
Wittenkeller J.L., Storer B., Bittner G.N., Schiller J.H.
Comparison of spontaneous and induced mutation rates in an immortalized human bronchial epithelial cell line and its tumorigenic derivative.
Oncology 54:335-341(1997)

Cross-references
Encyclopedic resources Wikidata; Q116049893
Entry history
Entry creation15-Dec-2022
Last entry update05-Oct-2023
Version number4