ID   FM6
AC   CVCL_C581
SY   FM-6; FM 6
DR   cancercelllines; CVCL_C581
DR   Cosmic; 808554
DR   Cosmic; 874437
DR   Cosmic; 972278
DR   Cosmic; 1047670
DR   Cosmic; 2163772
DR   ECACC; 13012409
DR   ESTDAB; ESTDAB-019
DR   GEO; GSM156021
DR   Progenetix; CVCL_C581
DR   Wikidata; Q54835054
RX   PubMed=7656272;
RX   PubMed=8968104;
RX   PubMed=9288767;
RX   PubMed=9688544;
RX   PubMed=15592718;
RX   PubMed=17260012;
RX   PubMed=23851445;
RX   PubMed=25728708;
CC   HLA typing: A*01,02; B*07,08 (PubMed=7656272).
CC   HLA typing: A*01:01,02:01; B*07:02,08:01; C*07:01:01,07:02; DPB1*04:01,01:01:01; DQB1*06:02,02:01; DRB1*03:01:01,15:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (PubMed=17260012; PubMed=25728708).
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: Metastatic; Not specified.
ST   Source(s): ECACC=13012409; ESTDAB=ESTDAB-019
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 11,12
ST   D3S1358: 14
ST   D5S818: 9,13
ST   D7S820: 9,10
ST   FGA: 23,24
ST   TH01: 9,9.3
ST   TPOX: 11,12
ST   vWA: 15,18
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=9688544; DOI=10.1016/S0014-5793(98)00603-6;
RA   Dzhandzhugazyan, Karine N.
RA   Kirkin, Alexei F.
RA   thor Straten, Per
RA   Zeuthen, Jesper
RT   "Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated
RT   human melanomas.";
RL   FEBS Lett. 430:227-230(1998).
//
RX   PubMed=9288767;
RA   Guldberg, Per
RA   thor Straten, Per
RA   Birck, Anette
RA   Ahrenkiel, Vibeke
RA   Kirkin, Alexei F.
RA   Zeuthen, Jesper
RT   "Disruption of the MMAC1/PTEN gene by deletion or mutation is a
RT   frequent event in malignant melanoma.";
RL   Cancer Res. 57:3660-3663(1997).
//
RX   PubMed=7656272; DOI=10.1007/BF01527402; PMCID=PMC11037630;
RA   Kirkin, Alexei F.
RA   Petersen, Troels Reichert
RA   Olsen, Anna Catharina
RA   Li, Li
RA   thor Straten, Per
RA   Zeuthen, Jesper
RT   "Generation of human-melanoma-specific T lymphocyte clones defining
RT   novel cytolytic targets with panels of newly established melanoma cell
RT   lines.";
RL   Cancer Immunol. Immunother. 41:71-81(1995).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez, Teresa
RA   Mendez, Rosa
RA   Roberts, Chrissy H.
RA   Ruiz-Cabello Osuna, Francisco
RA   Dodi, I. Anthony
RA   Lopez-Nevot, Miguel Angel
RA   Paco, Laura
RA   Maleno, Isabel
RA   Marsh, Steven G.E.
RA   Pawelec, Graham
RA   Garrido, Federico
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=17260012; DOI=10.1038/sj.onc.1210252;
RA   Jonsson, Goran
RA   Dahl, Christina
RA   Staaf, Johan
RA   Sandberg, Troy
RA   Bendahl, Par-Ola
RA   Ringner, Markus
RA   Guldberg, Per
RA   Borg, Ake
RT   "Genomic profiling of malignant melanoma using tiling-resolution
RT   arrayCGH.";
RL   Oncogene 26:4738-4748(2007).
//
RX   PubMed=25728708; DOI=10.1111/pcmr.12364;
RA   Vogel, Celia J.
RA   Smit, Marjon A.
RA   Maddalo, Gianluca
RA   Possik, Patricia Abrao
RA   Sparidans, Rolf W.
RA   van der Burg, Sjoerd Henricus
RA   Verdegaal, Elizabeth M.E.
RA   Heck, Albert J.R.
RA   Samatar, Ahmed A.
RA   Beijnen, Jos Heindrik
RA   Altelaar, A.F. Maarten
RA   Peeper, Daniel S.
RT   "Cooperative induction of apoptosis in NRAS mutant melanoma by
RT   inhibition of MEK and ROCK.";
RL   Pigment Cell Melanoma Res. 28:307-317(2015).
//
RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl, Christina
RA   Christensen, Claus
RA   Jonsson, Goran
RA   Lorentzen, Anders
RA   Skjodt, Mette Louise
RA   Borg, Ake
RA   Pawelec, Graham
RA   Guldberg, Per
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//
RX   PubMed=8968104;
RA   Bartkova, Jirina
RA   Lukas, Jiri
RA   Guldberg, Per
RA   Alsner, Jan
RA   Kirkin, Alexei F.
RA   Zeuthen, Jesper
RA   Bartek, Jiri
RT   "The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently
RT   altered in melanoma pathogenesis.";
RL   Cancer Res. 56:5475-5483(1996).
//