ID   PA682 PB
AC   CVCL_C539
SY   PA682(PB); PA682PB; Pa682PB; PA682; PA 682; PA-682
DR   cancercelllines; CVCL_C539
DR   Cosmic; 850212
DR   Cosmic; 931131
DR   Cosmic; 1515190
DR   Wikidata; Q54937379
RX   PubMed=1325212;
RX   PubMed=2052620;
RX   PubMed=2470097;
RX   PubMed=3026973;
RX   PubMed=3100061;
RX   PubMed=3927261;
RX   PubMed=6316501;
RX   PubMed=7519050;
RX   PubMed=8176200;
RX   PubMed=8568269;
RX   PubMed=9473234;
RX   PubMed=9787181;
RX   PubMed=9973220;
RX   PubMed=19358282;
RX   PubMed=24590883;
CC   Population: Caucasian; Norwegian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:5853; IGL + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGL (PubMed=7519050).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Val166Leu (c.496G>C); ClinVar=VCV000639793; Zygosity=Unspecified (PubMed=9787181).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_IV25 ! PA682 BM1
OI   CVCL_E4AT ! PA682 BM2
OI   CVCL_IV26 ! PA682 PE1
OI   CVCL_E4AU ! PA682 PE2
SX   Male
AG   30Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 16
//
RX   PubMed=1325212; DOI=10.1182/blood.V80.5.1289.1289;
RA   Benjamin D., Knobloch T.J., Dayton M.A.;
RT   "Human B-cell interleukin-10: B-cell lines derived from patients with
RT   acquired immunodeficiency syndrome and Burkitt's lymphoma
RT   constitutively secrete large quantities of interleukin-10.";
RL   Blood 80:1289-1298(1992).
//
RX   PubMed=2052620; DOI=10.1073/pnas.88.12.5413; PMCID=PMC51883;
RA   Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A.,
RA   Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.;
RT   "p53 mutations in human lymphoid malignancies: association with
RT   Burkitt lymphoma and chronic lymphocytic leukemia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991).
//
RX   PubMed=2470097; DOI=10.1073/pnas.86.9.3257; PMCID=PMC287109;
RA   Shtivelman E., Henglein B., Groitl P., Lipp M., Bishop J.M.;
RT   "Identification of a human transcription unit affected by the variant
RT   chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:3257-3260(1989).
//
RX   PubMed=3026973; DOI=10.1002/ijc.2910390215;
RA   Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.;
RT   "Expression of B-cell-specific markers in different Burkitt lymphoma
RT   subgroups.";
RL   Int. J. Cancer 39:211-218(1987).
//
RX   PubMed=3100061; DOI=10.1016/0008-8749(86)90099-7;
RA   Benjamin D., Bazar L.S., Wallace B., Jacobson R.J.;
RT   "Heterogeneity of B-cell growth factor receptor reactivity in healthy
RT   donors and in patients with chronic lymphatic leukemia: relationship
RT   to B-cell-derived lymphokines.";
RL   Cell. Immunol. 103:394-408(1986).
//
RX   PubMed=3927261; DOI=10.1093/nar/13.13.4921; PMCID=PMC321835;
RA   Sun L.-H.K., Croce C.M., Showe L.C.;
RT   "Cloning and sequencing of a rearranged V lambda gene from a Burkitt's
RT   lymphoma cell line expressing kappa light chains.";
RL   Nucleic Acids Res. 13:4921-4934(1985).
//
RX   PubMed=6316501; DOI=10.1126/science.6316501;
RA   Magrath I.T., Erikson J., Whang-Peng J., Sieverts H., Armstrong G.R.,
RA   Benjamin D., Triche T.J., Alabaster O., Croce C.M.;
RT   "Synthesis of kappa light chains by cell lines containing an 8;22
RT   chromosomal translocation derived from a male homosexual with
RT   Burkitt's lymphoma.";
RL   Science 222:1094-1098(1983).
//
RX   PubMed=7519050; DOI=10.1002/gcc.2870090408;
RA   Zeidler R., Joos S., Delecluse H.-J., Klobeck H.-G., Vuillaume M.,
RA   Lenoir G.M., Bornkamm G.-W., Lipp M.;
RT   "Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a
RT   distance of 300 kb downstream of MYC.";
RL   Genes Chromosomes Cancer 9:282-287(1994).
//
RX   PubMed=8176200; DOI=10.4049/jimmunol.152.10.4749;
RA   Benjamin D., Sharma V., Knobloch T.J., Armitage R.J., Dayton M.A.,
RA   Goodwin R.G.;
RT   "B cell IL-7. Human B cell lines constitutively secrete IL-7 and
RT   express IL-7 receptors.";
RL   J. Immunol. 152:4749-4757(1994).
//
RX   PubMed=8568269; DOI=10.4049/jimmunol.156.4.1626;
RA   Benjamin D., Sharma V., Kubin M., Klein J.L., Sartori A., Holliday J.,
RA   Trinchieri G.;
RT   "IL-12 expression in AIDS-related lymphoma B cell lines.";
RL   J. Immunol. 156:1626-1637(1996).
//
RX   PubMed=9473234; DOI=10.1182/blood.V91.5.1680;
RA   Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.;
RT   "p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a
RT   mRNA and protein expression in Burkitt's lymphoma.";
RL   Blood 91:1680-1687(1998).
//
RX   PubMed=9787181; DOI=10.1182/blood.V92.9.3410;
RA   Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.;
RT   "PTEN gene alterations in lymphoid neoplasms.";
RL   Blood 92:3410-3415(1998).
//
RX   PubMed=9973220;
RA   Gutierrez M.I., Cherney B.W., Hussain A., Mostowski H.S., Tosato G.,
RA   Magrath I.T., Bhatia K.G.;
RT   "Bax is frequently compromised in Burkitt's lymphomas with
RT   irreversible resistance to Fas-induced apoptosis.";
RL   Cancer Res. 59:696-703(1999).
//
RX   PubMed=19358282; DOI=10.1002/ijc.24351;
RA   Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M.,
RA   Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.;
RT   "Expression of the ULBP ligands for NKG2D by B-NHL cells plays an
RT   important role in determining their susceptibility to
RT   rituximab-induced ADCC.";
RL   Int. J. Cancer 125:212-221(2009).
//
RX   PubMed=24590883; DOI=10.1002/gcc.22161;
RA   Murga Penas E.-M., Schilling G., Behrmann P., Klokow M.,
RA   Vettorazzi E., Bokemeyer C., Dierlamm J.;
RT   "Comprehensive cytogenetic and molecular cytogenetic analysis of 44
RT   Burkitt lymphoma cell lines: secondary chromosomal changes
RT   characterization, karyotypic evolution, and comparison with primary
RT   samples.";
RL   Genes Chromosomes Cancer 53:497-515(2014).
//