Cell line name |
T84SF |
Accession |
CVCL_C4S3 |
Resource Identification Initiative |
To cite this cell line use: T84SF (RRID:CVCL_C4S3) |
Comments |
Population: Caucasian. Characteristics: Metastatic. Selected by repetitive plating on TNFA-activated human endothelial cells and subsequent selection for adherent cells (PubMed=15484219). Derived from site: Metastatic; Lung; UBERON=UBERON_0002048. |
Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Leu1488Phefs*19 (c.4464delA); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Lys340Asn (c.1020G>C); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.560-1G>T; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0555 (T84) |
Sex of cell |
Male |
Age at sampling |
72Y |
Category |
Cancer cell line |
Publications | PubMed=15484219; DOI=10.1002/jcp.20236 Alessandro R., Flugy A.M., Russo D., Stassi G., De Leo A., Corrado C., Alaimo G., De Leo G. Identification and phenotypic characterization of a subpopulation of T84 human colon cancer cells, after selection on activated endothelial cells. J. Cell. Physiol. 203:261-272(2005) PubMed=16612624; DOI=10.1007/s00428-006-0179-4 Alessandro R., Di Bella M.A., Flugy A.M., Fontana S., Damiani F., Corrado C., Colomba P., Todaro M., Russo D., Santoro A., Kohn E.C., De Leo G. Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis. Virchows Arch. 449:48-61(2006) |
Cross-references |
Encyclopedic resources |
Wikidata; Q116050626
|
Entry history |
Entry creation | 15-Dec-2022 |
Last entry update | 29-Jun-2023 |
Version number | 3 |
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