ID   VeroE6-Pgp-KO
AC   CVCL_C4RQ
DR   Wikidata; Q116050765
RX   PubMed=36208677;
CC   Group: Non-human primate cell line.
CC   Group: SARS-CoV-2 research cell line.
CC   Virology: Can be used for in vitro virus infection system for SARS-CoV-2 and possibly other viruses to test antiviral therapies without a need to control the ABCB1/Pgp efflux transporter activity (PubMed=36208677).
CC   Knockout cell: Method=CRISPR/Cas9; UniProtKB; A0A0D9RIY5; ABCB1.
CC   Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
OX   NCBI_TaxID=60711; ! Chlorocebus sabaeus (Green monkey)
HI   CVCL_0574 ! Vero C1008
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 15-12-22; Last updated: 05-10-23; Version: 4
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RX   PubMed=36208677; DOI=10.1016/j.antiviral.2022.105429;
RA   Zhu Y., Binder J., Yurgelonis I., Rai D.K., Lazarro S., Costales C.,
RA   Kobylarz K., McMonagle P., Steppan C.M., Aschenbrenner L.,
RA   Anderson A.S., Cardin R.D.;
RT   "Generation of a VeroE6 Pgp gene knock out cell line and its use in
RT   SARS-CoV-2 antiviral study.";
RL   Antiviral Res. 208:105429.1-105429.6(2022).
//