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Cellosaurus RBL SX-38 (CVCL_C4MP)

[Text version]
Cell line name RBL SX-38
Synonyms RBL-SX38; RBL-2H3-SX38; SX-38
Accession CVCL_C4MP
Resource Identification Initiative To cite this cell line use: RBL SX-38 (RRID:CVCL_C4MP)
Comments Biotechnology: Can be used in human allergy assays. Because it expresses human Fc-epsilon RI, following sensitization with IgE from a subset of allergic donors, these cells can be triggered by exposure to anti-IgE or to very low concentrations of specific allergen.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3609; FCER1A.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7316; MS4A2.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3611; FCER1G.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: ChEBI; CHEBI_232042; Beta-chloro-N-isopropyl-2-naphthaleneethanamine hydrochloride (ICI 42464).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Basophil; CL=CL_0000767.
Disease Rat leukemia (NCIt: C60428)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar; RS=RS:0000955.
Hierarchy Parent: CVCL_0591 (RBL-2H3)
Category Cancer cell line
Publications

PubMed=8683119; DOI=10.4049/jimmunol.157.1.221
Wiegand T.W., Williams P.B., Dreskin S.C., Jouvin M.-H., Kinet J.-P., Tasset D.
High-affinity oligonucleotide ligands to human IgE inhibit binding to Fc epsilon receptor I.
J. Immunol. 157:221-230(1996)

PubMed=12609531; DOI=10.1016/S0022-1759(02)00369-1
Dibbern D.A. Jr., Palmer G.W., Williams P.B., Bock S.A., Dreskin S.C.
RBL cells expressing human Fc epsilon RI are a sensitive tool for exploring functional IgE-allergen interactions: studies with sera from peanut-sensitive patients.
J. Immunol. Methods 274:37-45(2003)

PubMed=18534732; DOI=10.1016/j.yrtph.2008.04.012
Ladics G.S., van Bilsen J.H.M., Brouwer H.M.H., Vogel L., Vieths S., Knippels L.M.J.
Assessment of three human FcepsilonRI-transfected RBL cell-lines for identifying IgE induced degranulation utilizing peanut-allergic patient sera and peanut protein extract.
Regul. Toxicol. Pharmacol. 51:288-294(2008)

PubMed=19538351; DOI=10.1111/j.1365-2222.2009.03294.x
Blanc F., Adel-Patient K., Drumare M.-F., Paty E., Wal J.-M., Bernard H.
Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors.
Clin. Exp. Allergy 39:1277-1285(2009)

PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8
Passante E.
Mast cell and basophil cell lines: a compendium.
Methods Mol. Biol. 1192:101-113(2014)

Cross-references
Encyclopedic resources Wikidata; Q116050162
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number5