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Cellosaurus SKOV3.ip1 PEA-15-WT (CVCL_C4JB)

[Text version]
Cell line name SKOV3.ip1 PEA-15-WT
Accession CVCL_C4JB
Resource Identification Initiative To cite this cell line use: SKOV3.ip1 PEA-15-WT (RRID:CVCL_C4JB)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:8822; PEA15 (Note=With a N-terminal HA tag).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0C84 (SKOV3.ip1)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=23552738; DOI=10.1038/oncsis.2012.22; PMCID=PMC3412650
Lee J., Bartholomeusz C., Krishnamurthy S., Liu P., Saso H., LaFortune T.A., Hortobagyi G.N., Ueno N.T.
PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking beta-catenin.
Oncogenesis 1:e22.1-e22.11(2012)

Cross-references
Encyclopedic resources Wikidata; Q116050517
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number5