ID   hTERT-HPNE E6/E7/K-RasG12D/st
AC   CVCL_C470
DR   ATCC; CRL-4039
DR   Wikidata; Q54896628
RX   PubMed=17332339;
CC   Doubling time: ~31 hours (ATCC=CRL-4039).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6407; KRAS (Note=With p.Gly12Asp (c.35G>A)).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
CC   Cell type: Pancreatic ductal cell; CL=CL_0002079.
ST   Source(s): ATCC=CRL-4039
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 12,13
ST   D16S539: 12,13
ST   D18S51: 13,16
ST   D19S433: 12,16.2
ST   D21S11: 30
ST   D2S1338: 17,22
ST   D3S1358: 15
ST   D5S818: 11
ST   D7S820: 9,10
ST   D8S1179: 10,13
ST   FGA: 23,24
ST   Penta D: 11
ST   Penta E: 7,10
ST   TH01: 8,9
ST   TPOX: 8,11
ST   vWA: 17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C469 ! hTERT-HPNE E6/E7/K-RasG12D
SX   Male
AG   52Y
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 17
//
RX   PubMed=17332339; DOI=10.1158/0008-5472.CAN-06-3752;
RA   Campbell P.M., Groehler A.L., Lee K.M., Ouellette M.M., Khazak V.,
RA   Der C.J.;
RT   "K-Ras promotes growth transformation and invasion of immortalized
RT   human pancreatic cells by Raf and phosphatidylinositol 3-kinase
RT   signaling.";
RL   Cancer Res. 67:2098-2106(2007).
//