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Cellosaurus CuFi-1 (CVCL_C457)

[Text version]
Cell line name CuFi-1
Synonyms CuFi1; Cystic Fibrosis, University of Iowa-1
Accession CVCL_C457
Resource Identification Initiative To cite this cell line use: CuFi-1 (RRID:CVCL_C457)
Comments Karyotypic information: 47,XX,+20 [16]; 46,XX [4] (PubMed=12676769).
Genetic integration: Method=Transduction; Gene=HGNC; 11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations
  • Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=12676769).
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 14Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-4013

Markers:
AmelogeninX
CSF1PO12
D2S133819,22
D3S135814,15
D5S81812
D7S8208,11
D8S117911
D13S31711,13
D16S53911,14
D18S5117,19
D19S43313,14
D21S1129,30
FGA19,26
Penta D12
Penta E14,16
TH016,9.3
TPOX8,11
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=12676769; DOI=10.1152/ajplung.00355.2002
Zabner J., Karp P., Seiler M., Phillips S.L., Mitchell C.J., Saavedra M.T., Welsh M., Klingelhutz A.J.
Development of cystic fibrosis and noncystic fibrosis airway cell lines.
Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L844-L854(2003)

PubMed=17191107; DOI=10.1007/s10238-006-0116-5
Gambardella S., Biancolella M., D'Apice M.R., Amati F., Sangiuolo F., Farcomeni A., Chillemi G., Bueno S., Desideri A., Novelli G.
Gene expression profile study in CFTR mutated bronchial cell lines.
Clin. Exp. Med. 6:157-165(2006)

Cross-references
Cell line collections (Providers) ATCC; CRL-4013
Biological sample resources BioSample; SAMN03471722
Chemistry resources ChEMBL-Cells; CHEMBL4513116
ChEMBL-Targets; CHEMBL4513124
PubChem_Cell_line; CVCL_C457
Encyclopedic resources Wikidata; Q54814854
Entry history
Entry creation22-Oct-2012
Last entry update10-Sep-2024
Version number25