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Cellosaurus 7G3 (CVCL_C3X5)

[Text version]
Cell line name 7G3
Accession CVCL_C3X5
Resource Identification Initiative To cite this cell line use: 7G3 (RRID:CVCL_C3X5)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized talacotuzumab (CSL362) therapeutic antibody which was used in clinical trials for the treatment of acute myeloid leukemia.
Monoclonal antibody isotype: IgG2a.
Monoclonal antibody target: UniProtKB; P26951; Human IL3RA/CD123.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_2155 (P3/NS1/1-Ag4.1)
Category Hybridoma
Publications

PubMed=8547680; DOI=10.1182/blood.V87.1.83.83
Sun Q.-Y., Woodcock J.M., Rapoport A.P., Stomski F.C., Korpelainen E.I., Bagley C.J., Goodall G.J., Smith W.B., Gamble J.R., Vadas M.A., Lopez A.F.
Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.
Blood 87:83-92(1996)

Cross-references
Encyclopedic resources Wikidata; Q116048406
Entry history
Entry creation15-Dec-2022
Last entry update21-Mar-2023
Version number2