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Cellosaurus RK35 (CVCL_C3VG)

[Text version]
Cell line name RK35
Accession CVCL_C3VG
Resource Identification Initiative To cite this cell line use: RK35 (RRID:CVCL_C3VG)
Comments Group: Patented cell line.
Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized domagrozumab (PF-06252616) therapeutic antibody which was used in clinical trials for the treatment of Duchenne muscular dystrophy.
Monoclonal antibody isotype: Not specified.
Monoclonal antibody target: UniProtKB; O14793; Human MSTN.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=16837207; DOI=10.1016/j.nbd.2006.05.009
Holzbaur E.L.F., Howland D.S., Weber N., Wallace K., She Y.-J., Kwak S.P., Tchistiakova L.G., Murphy E., Hinson J., Karim R., Tan X.-Y., Kelley P., McGill K.C., Williams G., Hobbs C., Doherty P., Zaleska M.M., Pangalos M.N., Walsh F.S.
Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis.
Neurobiol. Dis. 23:697-707(2006)

Patent=US9926368
Walsh F.S., Zaleska M.M., Howland D.S., Tchistiakova L.G., Karim R., Kelley P., Tan X.-Y., Kwak S.P., Pangalos M.N.
Method for treating muscle wasting syndrome using antagonist antibodies against GDF-8.
Patent number US9926368, 27-Mar-2018

Cross-references
Biological sample resources ABCD; ABCD_AI744
Encyclopedic resources Wikidata; Q116050176
Entry history
Entry creation15-Dec-2022
Last entry update21-Mar-2023
Version number2