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Cellosaurus 1321N1 RHOA KO (CVCL_C3IR)

[Text version]
Cell line name 1321N1 RHOA KO
Synonyms 1321N1-Rho KO
Accession CVCL_C3IR
Resource Identification Initiative To cite this cell line use: 1321N1 RHOA KO (RRID:CVCL_C3IR)
Comments Problematic cell line: Contaminated. Ancestral cell line (U-118MG) has been shown to be a U-138MG derivative.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:667; RHOA.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0110 (1321N1)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=29887596; DOI=10.1038/s41388-018-0301-5; PMCID=PMC6195840
Yu O.M., Benitez J.A., Plouffe S.W., Ryback D., Klein A., Smith J., Greenbaum J., Delatte B., Rao A., Guan K.-L., Furnari F.B., Chaim O.M., Miyamoto S., Brown J.H.
YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.
Oncogene 37:5492-5507(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3IR
Encyclopedic resources Wikidata; Q114310344
Gene expression databases GEO; GSM3034471
GEO; GSM3034472
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6