ID   U-87MG-parkin clone 25
SY   U-87MG-PK25; U87-Parkin 25
DR   cancercelllines; CVCL_C3IG
DR   GEO; GSM729741
DR   GEO; GSM729744
DR   GEO; GSM729747
DR   Wikidata; Q114313143
RX   PubMed=22431710;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 8607; PRKN (with a N-terminal FLAG tag).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 4
RX   PubMed=22431710; DOI=10.1158/0008-5472.CAN-11-3060;
RA   Yeo C.W.-S., Ng F.S.L., Chai C., Tan J.M.-M., Koh G.R.-H., Chong Y.K.,
RA   Koh L.W.H., Foong C.S.F., Sandanaraj E., Holbrook J.D., Ang B.-T.,
RA   Takahashi R., Tang C., Lim K.-L.;
RT   "Parkin pathway activation mitigates glioma cell proliferation and
RT   predicts patient survival.";
RL   Cancer Res. 72:2543-2553(2012).